Tissue Research
TB-500 10mg
Buy TB-500 10mg in Australia — >99.6% HPLC tested with batch-specific COA. Same-day Australian dispatch.
Thymosin Beta-4 fragment research compound. Actin-binding peptide investigated in tissue remodelling and angiogenic signalling.
Institutional pricing
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TB-500 10mg
Estimated launch price: $89 AUD
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Researchers studying TB-500 frequently study
Tissue Research Bundle
Distinct mechanisms, single supply.
$227
$204
Comparative Tissue + Blend Kit
Single compounds plus the co-lyophilised blend for additive-effect studies.
$297
$261
BPC-157 10mg
BPC-157 + TB-500 Blend
GHK-Cu
TB-500 Overview
TB-500 is a synthetic peptide derived from Thymosin Beta-4 (Tβ4), a 43-amino-acid actin-binding protein present in nearly all human and animal cells and originally isolated from the thymus gland. The peptide retains the active region responsible for actin sequestration and signalling, supporting research into cytoskeletal remodelling, cell migration, and tissue regeneration.
History
Thymosin Beta-4 was first isolated in the late 1960s. The synthetic TB-500 form has been investigated in cardiovascular, ophthalmic, and dermatological research models, with published preclinical data spanning angiogenic and anti-inflammatory pathways.
TB-500 Structure
Research Findings
TB-500 has been studied in tissue regeneration, angiogenesis, anti-inflammatory signalling, and cardiovascular research. The actin-binding mechanism underlies cytoskeletal remodelling, while secondary effects modulate inflammatory cytokine profiles in published preclinical models.
Key Areas of Research:
- •Cytoskeletal: G-actin sequestration and polymerisation dynamics
- •Angiogenic: Vascular formation in preclinical models
- •Anti-inflammatory: Cytokine modulation in tissue research
- •Cardiovascular: Cardiac repair and ischaemic models
The combination of cytoskeletal regulation and angiogenic signalling makes TB-500 a versatile research tool for tissue-remodelling investigations, often paired with BPC-157 in comparative protocols probing distinct molecular mechanisms.
Sosne G. et al. (2010). Thymosin beta-4 in clinical and experimental wound healing.
References
References are provided for research context. Pillar Research does not endorse or interpret published findings as therapeutic claims.
TB-500 10mg — research questions
Common questions for Australian researchers about TB-500 10mg.
What is TB-500?
TB-500 is a synthetic peptide derived from Thymosin Beta-4, a 43-amino-acid actin-binding protein. It is supplied as an investigational research compound for in vitro laboratory research under the RUO framework.
How does TB-500 work in preclinical models?
TB-500 sequesters G-actin monomers, modulating the equilibrium between G-actin and F-actin polymerisation that underlies cytoskeletal remodelling, cell migration, and tissue regeneration. Secondary effects in published preclinical work include angiogenic signalling and anti-inflammatory cytokine modulation.
How is TB-500 different from BPC-157?
BPC-157 acts on signalling cascades (nitric oxide, growth factors, FAK-paxillin) while TB-500 acts on the cytoskeleton directly via actin sequestration. Both are investigated in tissue research but through distinct molecular pathways.
Is TB-500 legal in Australia?
TB-500 is classified as Schedule 4 (prescription-only) under the Australian Poisons Standard. It can be lawfully supplied for in vitro research purposes under the Research Use Only (RUO) framework. It is not listed on the Australian Register of Therapeutic Goods (ARTG) and is not a therapeutic good under the Therapeutic Goods Act 1989 (Cth).
How is TB-500 verified by Pillar Research?
Every batch is independently HPLC and mass spectrometry verified by a third-party Australian laboratory. The batch-specific Certificate of Analysis is downloadable from this page.
How should TB-500 be stored?
Store lyophilised vials at 2–8 °C, protected from light and moisture, in the original sealed vial. After reconstitution, store at 2–8 °C for short-term use or −20 °C for longer storage. Avoid repeated freeze–thaw cycles.